abstract：:Numbers of B, T and total lymphocytes, monocytes, heterophils, eosinophils and basophils have been examined in the peripheral blood of chickens between 2 and 42 days after infection with Marek's disease virus. During the stage of the acute restrictively productive virus infection of lymphoid tissues at 2-9 days after ...

journal_title：International journal of cancer

authors： Payne LN,Rennie M

更新日期：1976-10-15 00:00:00

abstract：:Benzo(a)pyrene and benz(a) anthrancene which, in contrast to the K-region epoxides benzo(a)pyrene 4,5-oxide and benz(a)anthracene 5,6-oxide, are not mutagenic to Salmonella typhimurium TA 1537 in the absence of mammalian enzyme preparations, were activated by liver microsomes from C3H mice, which had not received any ...

journal_title：International journal of cancer

authors： Oesch F,Bentley P,Glatt HR

更新日期：1976-10-15 00:00:00

abstract：:Immunological studies are presented on a patient with a long clinical history suggesting the existence of a tumor-specific immune response. His tumor, first considered benign, progressed to a highly malignant osteosarcoma. Cell-mediated immune reactivity against biopsy cells and against tumor extract was detected in v...

journal_title：International journal of cancer

authors： Vanky F,Klein E,Cornain S,Bakács T,Stjernswärd J,Nilsonne U

更新日期：1976-09-15 00:00:00

abstract：:An antiserum to SF antigen was shown to be selectively cytotoxic to two human fibroblast lines, while two tumor cell lines (one melanoma and one Hela cell line) were resistant. The selective cytotoxicity was also demonstrable in mixtures of fibroblasts and tumor cells. The cytotoxic effect was abrogated by admixture o...

journal_title：International journal of cancer

authors： Ruoslahti E,Sjögren HO

更新日期：1976-09-15 00:00:00

abstract：:General cell-mediated immune (CMI) functions in NPC patients were investigated by the in vivo Mantoux and in vitro lymphocyte response to PHA assays. Thirty-eight (50%) of 76 untreated NPC patients were hyporesponsive in the Mantoux assay compared to 27 (25%) of 110 control patients. Forty-three (65.2%) of 66 untreate...

journal_title：International journal of cancer

authors： Chan SH,Chew TS,Goh EH,Simons MJ,Shanmugaratnam K

更新日期：1976-08-15 00:00:00

abstract：:The peripheral blood monocyte is the reactive cell in the tube LAI assay. The monocyte loses its properties of adherence to glass upon exposure to specific antigen. Two different experiments to determine if lymphocytes, when they reacted with tumour, released mediators that were responsible for inhibiting monocyte gla...

journal_title：International journal of cancer

authors： Marti JH,Grosser N,Thomson DM

更新日期：1976-07-15 00:00:00

abstract：:Receptors for the third component of complement (C3) were demonstrated on the surface of established human lymphoid cell lines by a membrane fluorescence test with FITC- or TRITC-conjugated antibodies against human C3. Two-color fluorescence staining of EBV receptors and C3 receptors showed complete overlapping of gre...

journal_title：International journal of cancer

authors： Yefenof E,Klein G,Jondal M,Oldstone MB

更新日期：1976-06-15 00:00:00

abstract：:A new antigan has been revealed by means of antisera against Rauscher virus in mice with Rauscher virus-induced leukemia. This antigen appears to be different from both Rauscher type-specific antigen and MULV-gs-1 (p-30), as shown by studies of electrophoretic mobility and immunochemical specificity. Except in leukemi...

journal_title：International journal of cancer

authors： Ievleva ES,Engelhardt NV,Abelev GI

更新日期：1976-06-15 00:00:00

abstract：:The radiosensitivity of three forms of response to injection of C. parvum in mice has been investigated. The increase in phagocytin index evoked by IP or IV injection of 0.7 mg C. parvum (but not that evoked by 1.4 mg) was reduced but not abolished in mice given 350-500 rad whole-body irradiation 4 days before C. parv...

journal_title：International journal of cancer

authors： Woodruff MF,Ghaffar A,Whitehead VL

更新日期：1976-05-15 00:00:00

abstract：:Extracts were made from Walker 256 carcinoma, spontaneous rat mammary adenocarcinoma, Wilms' tumour, human neuroblastoma and human haemangioma. Chromatography of the extracts on Sephadex G-100 yielded four fractions, A, B, C and D. Injection of fractions B and C resulted in the growth of new capillaries in the subcuta...

journal_title：International journal of cancer

authors： Phillips P,Steward JK,Kumar S

更新日期：1976-05-15 00:00:00

abstract：:Eight squirrel monkeys (Saimiri sciureus) challenged with EBV or EBV-transformed SLCL were naturally or experimentally infected with Plasmodium knowlesi or Pl. brasilianum. Most of the animals had been splenectomized and unilaterally nephrectomized. Three of these monkeys received one dose of 6 to 12 X 10(8) autologou...

journal_title：International journal of cancer

authors： Leibold W,Huldt G,Flanagan TD,Andersson M,Dalens M,Wright DH,Voller A,Klein G

更新日期：1976-04-15 00:00:00

abstract：:A randomized clinical trial designed to compare the effectiveness of cytoxan (CTX) alone versus a combination consisting of CTX, vincristine (Oncovin) and methotrexate (COM) in the treatment of Burkitt's lymphoma (BL) was carried out. Nineteen patients were selected at random to receive CTX alone while 21 received COM...

journal_title：International journal of cancer

authors： Olweny CL,Katongole-Mbidde E,Kaddu-Mukasa A,Atine I,Owor R,Lwanga S,Carswell W,Magrath IT

更新日期：1976-04-15 00:00:00

abstract：:An experiment in which rats were injected intrapleurally with asbestos, the injection taking place at an age of either 2 or 10 months, is reported. In the former group 19 out of 48 rats developed a mesothelioma compared with 17 out of 90 in the latter group. However, by considering the two groups at equal times after ...

journal_title：International journal of cancer

authors： Berry G,Wagner JC

更新日期：1976-04-15 00:00:00

abstract：:Studies of the MLTI were performed in a primary MSV-induced tumor system. Reactivity against mitomycin-C-treated RBL-5 cells could be detected during a limited period at about 14 days after virus injection. The degree of reactivity of MSV 14 spleen cells was quite variable; stimulation indices ranged from 2.2 to 9.4. ...

journal_title：International journal of cancer

authors： Kirchner H,Glaser M,Holden HT,Herberman RB

更新日期：1976-03-15 00:00:00

abstract：:The levels of tumour-specific antigen, antibody and specific immune complexes in the sera of rats bearing lung nodules of a chemically induced rat hepatoma, produced by intravenous inoculation of viable tumour cells, have been examined and compared with the levels of serum factors in animals actively immunized by intr...

journal_title：International journal of cancer

authors： Bowen JG,Baldwin RW

更新日期：1976-02-15 00:00:00

abstract：:The karyotypes of cells from 10 Burkitt lymphoma (BL) biopsies, eight cell lines established from BL and nine cell lines from non-BL sources were studied by chromosome banding techniques. With the exception of the BL-derived cell lines BJAB, GC-BJAB, Maku and U-8691 all biopsies and lines of Burkitt origin contained a...

journal_title：International journal of cancer

authors： Zech L,Haglund U,Nilsson K,Klein G

更新日期：1976-01-15 00:00:00

abstract：:In a series of consecutive 51chromium (51Cr) assays, 21 melanoma and 14 colo-rectal carcinoma patients were tested for their in vitro cell-mediated immune reactions to melanoma, rectal adenocarcinoma, and normal fibroblast target cells. Blood lymphocytes (BL) from four individuals were included in each experiment. In ...

journal_title：International journal of cancer

authors： Steele G Jr,Sjögren HO,Stadenberg I

更新日期：1976-01-15 00:00:00

abstract：:Stimulated by a report on elevated IgA levels in nasopharyngeal carcinoma (NPC), we tested a total of 372 sera from patients with NPC, other carcinomas of head and neck or elsewhere, Burkitt's lymphoma (BL), infectious mononucleosis (IM) or healthy controls. The sera were titrated in indirect immunofluorescence tests ...

journal_title：International journal of cancer

authors： Henle G,Henle W

更新日期：1976-01-15 00:00:00

abstract：:The interactions which occur between antigenic tumor cells and normal or immune lymphoid cells in a 3-day in vitro culture, have been studied with a murine sarcoma virus (MSV)-induced tumor. The 3H-thymidine incorporation of lymphoma cells growing in suspension, and the radioactive-chromium release of freshly sampled ...

journal_title：International journal of cancer

authors： Senik A,Hebrero FP,Levy JP

更新日期：1975-12-15 00:00:00

abstract：:By radioimmunoassay (RIA) mammary tumour virus (MTV) antigens were detected in individual milk samples of C3Hf mice, (female BALB/c X male C3Hf)F1 mice and (female C3Hf X male BALB/c)F1 mice; milk samples of BALB/c mice were negative. In the segregating backcross I population, female BALB/c X male (female BALB/c X mal...

journal_title：International journal of cancer

authors： van Nie R,Verstraeten AA

更新日期：1975-12-15 00:00:00

abstract：:Lymphocyte blastogenesis induced by autologous tumor biopsy cells, by allogeneic lymphocytes and by PHA, was performed in the presence of autologous or allogeneic serum collected from normal blood donors. In 13 of the 15 cases lymphocyte stimulation by autologous tumor cells was inhibited in the presence of autologous...

journal_title：International journal of cancer

authors： Vánky F,Klein E,Stjernswärd J,Trempe G

更新日期：1975-11-15 00:00:00

abstract：:Complement-dependent cytotoxicity against melanoma cells was demonstrated with a microassay in sera from melanoma patients. The response was tumor-specific and histologic type-specific since 16 out of 52 (30%) melanoma patient sera taken before surgery reacted against melanoma cells, whereas 3 out of 43 (7%) control s...

journal_title：International journal of cancer

authors： Canevari S,Fossati G,Della Porta G,Balzarini GP

更新日期：1975-11-15 00:00:00

abstract：:Chloroethylene oxide and 2-chloroacetaldehyde, two possibly carcinogenic metabolities of vinyl chloride in mammals, caused a dose-dependent induction of 8-azaguanine- and ouabain-resistant mutants in Chinese hamster V79 cells in vitro. Up to one-hundred-fold higher concentrations of 2-chloroethanol or monochloroacetic...

journal_title：International journal of cancer

authors： Huberman E,Bartsch H,Sachs L

更新日期：1975-10-15 00:00:00

abstract：:Spleen cells from BALB/c mice bearing syngeneic, methylcholanthrene-induced sarcomas were cultured in vitro. In agreement with previous observations, two tumor-specific activities could be demonstrated in the culture supernatants: the supernatants suppressed (blocked) specific lymph-node cell-mediated cytotoxicity dir...

journal_title：International journal of cancer

authors： Nelson K,Pollack SB,Hellström KE

更新日期：1975-10-15 00:00:00

abstract：:W/Fu rats were injected subcutaneously with low numbers of cells from the Gross leukemia virus-induced lymphoma, (C58NT)D, which induced transient tumor growth and regression (regressors), or with high numbers of tumor cells resulting in progressive tumor growth (progressors). Spleen cells from regressors had a signif...

journal_title：International journal of cancer

authors： Glaser M,Kirchner H,Herberman RB

更新日期：1975-09-15 00:00:00

abstract：:We have shown in the preceding paper that AKR mice are highly resistant to M-MSV tumor development, and that resistance is transmitted as a dominant character. In the present studies the tumor-response pattern of F1 hybrids between resistant AKR and susceptible strains (C57Bl/6, BALB/c and B10BR) following injection w...

journal_title：International journal of cancer

authors： Colombatti A,Collavo D,Biasi G,Chieco-Bianchi L

更新日期：1975-09-15 00:00:00

abstract：:Sprague-Dawley rats were given combinations of aminopyrine or oxytetracycline and sodium nitrite in drinking water. Of 30 animals receiving 0.1% (1,000 ppm) of aminopyrine and sodium nitrite for 30 weeks, 29 died with hemangioendothelial sarcomas of the liver. The same tumor caused death in 26 of 30 animals that recei...

journal_title：International journal of cancer

authors： Taylor HW,Lijinsky W

更新日期：1975-08-15 00:00:00

abstract：:Studies were performed to characterize the effector cells responsible for natural cytotoxicity of mouse lymphoid cells against a variety of syngeneic and allogeneic tumor lines. Since spleen cells from normal nude mice were found to be highly cytotoxic, they were used for most of these experiments. Only a small propor...

journal_title：International journal of cancer

authors： Herberman RB,Nunn ME,Holden HT,Lavrin DH

更新日期：1975-08-15 00:00:00

abstract：:A continuous lymphoma cell line, BJAB, derived from the tumour of an exceptional African case of Burkitt's lymphoma, has previously been described. Unlike 97% of African BL cases studied, neither the original tumour cells nor the cell line contained detectable amounts of EBV (Epstein-Barr virus) DNA, nor did they expr...

journal_title：International journal of cancer

authors： Clements GB,Klein G,Povey S

更新日期：1975-07-15 00:00:00

abstract：:The present experiments were performed to investigate the possibility of inhibiting tumor growth in vivo with syngeneic lymphocytes sensitized in vitro on monolayers of the tumor under test, and to study the effect of a thymic humoral factor (THF) in this sensitization process. Monolayers of fibrosarcoma cells were us...

journal_title：International journal of cancer

authors： Small M,Trainin N

更新日期：1975-06-15 00:00:00

abstract：:Hooded rats bearing a syngeneic methylcholanthrene-induced tumour were evaluated for extent of in vivo host immunity and this was correlated by in vitro techniques with the levels of circulating tumour antigen and specific antibody. Early tumour growth was associated with detectable immunity, as measured by the capaci...

journal_title：International journal of cancer

authors： Thomson DM

更新日期：1975-06-15 00:00:00

abstract：:An epithelioid cell line, started from a human pancreatic carcinoma of ductal cell origin, has been maintained in culture for over 2 years and has been subcultured more than 40 times. The PANC-1 cell line has a doubling time of 52 h and G6PD activity of the slow mobility of B type. Chromosome studies show a modal numb...

journal_title：International journal of cancer

authors： Lieber M,Mazzetta J,Nelson-Rees W,Kaplan M,Todaro G

更新日期：1975-05-15 00:00:00

abstract：:The expression of the nuclear SV40-induced T antigen was measured by microfluorimetry on individual, asynchronously growing SV40-transformed cells which had been stained with hamster T-antiserum by the indirect immunofluorescence method. The same individual cells were first measured for T antigen and then for DNA by F...

journal_title：International journal of cancer

authors： Stenman S,Zeuthen J,Ringertz NR

更新日期：1975-04-15 00:00:00

abstract：:The effect on tumor progression produced by the injection of VCN-treated tumor cells in dogs with spontaneous mammary tumors was investigated. Untreated dogs of different races and different ages with at least two palpable spontaneous mammary tumors were selected. One of the tumors was left in the animal for further c...

journal_title：International journal of cancer

authors： Sedlacek HH,Meesmann H,Seiler FR

更新日期：1975-03-15 00:00:00

abstract：:Peripheral blood leukocytes from patients with confirmed pulmonary neoplasia were tested for cytotoxicity against cultured cells derived from lung tumours of various histological types, foetal and normal adult lung tissue and tumours arising in organs other than the lung. Leukocytes from 73 percent of patients were cy...

journal_title：International journal of cancer

authors： Vose BM,Moore M,Jack GD

更新日期：1975-02-15 00:00:00

abstract：:A clone of Cloudman S91 murine melanoma was fused in vitro with non-malignant hamster cheek pouch cells by means of lysolecithin, and the putative hybrid progeny cells, HCP-MM, were found to be highly malignant in hamster, but not in appropriate mice. A malignant clone of HCP-MM cells was shown to have hamster species...

journal_title：International journal of cancer

authors： Goldenberg DM,Pavia RA

更新日期：1975-02-15 00:00:00

abstract：:A single treatment of chick embryo fibroblasts with DNA recovered from chick embryo fibroblasts productively infected and transformed with four different strains of RSV, or productively infected with two different strains of RAV, resulted in virus production and cell transformation (in the case of RSV) two or three p...

journal_title：International journal of cancer

authors： Vigier P,Montagnier L

更新日期：1975-01-15 00:00:00

abstract：:Rabbits were immunized with extracts of primary or grafted intestinal adeno-carcinomas induced by carcinogenic drugs in inbred rats. After absorption with normal tissue extracts, the antisera were able to recognize three tumor-associated antigens. Two of them were glycoproteins, present in cancer cells but also, in tr...

journal_title：International journal of cancer

authors： Martin F,Martin MS,Bordes M,Knobel S

更新日期：1975-01-15 00:00:00

abstract：:Cells from reticulum-cell sarcomas (RCS), tumors with a probable B-cell origin in the SJL/J mouse strain, induced a high degree of proliferation in O-bearing syngeneic lymph-node and thymus cells obtained from young non-tumours mice. Although of considerably lower magnitude, a proliferation of SJL/J thymus cells to sy...

journal_title：International journal of cancer

authors： Lerman SP,Chapman JM,Carswell EA,Thorbecke GJ

更新日期：1974-12-15 00:00:00

abstract：:Streptovaricins (Sv), ansa macrolide antibiotics, inhibited Rauscher leukemia virus (RLV) splenomegaly by 25-50%. All streptovaricins tested were effective when administered orally either by diet ad lib or by intubation from infection to time of killing. When delivered by intubation, Sv was measurable in plasma for up...

journal_title：International journal of cancer

authors： Borden EC,Carter WA,Sensenbrenner LL,Owens AH,Lichtenstein J,Gray GD,Neil GL,Nichol FR,Li LH

更新日期：1974-12-15 00:00:00